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There are several medications you can try to help relieve the itching of eczema. Topical treatments including calamine lotion, which helps soothe the itching. Another topical herpesyl reviews option is an over-the-counter cream that contains one percent hydrocortisone. For severe itching, consider an oral over-the-counter antihistamine, such as Benadryl. Follow the instructions on the package, and remember that antihistamines may cause drowsiness.